Dicumaol R: Full Drug Profile

Dicumaol R - General Information

An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. [PubChem]

Pharmacology of Dicumaol R

Dicumaol R is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It is also used in biochemical experiments as an inhibitor of reductases.

Additional information about Dicumaol R

Dicumaol R Indication

For decreasing blood clotting

Mechanism Of Action

Dicumaol R inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.

Generic Name

Dicumarol

Synonyms

Dicoumarol; Bis-Hydroxycoumarin; BHC; Bishydroxycoumarin; Dicoumarin

Drug Category

Uncoupling Agents; Anticoagulants; Enzyme Inhibitors

Drug Type

Small Molecule; Approved

Other Brand Names containing Dicumarol

Acadyl; Acavyl; Antitrombosin; Baracoumin; Cuma; Cumid; Dicoumal; Dicuman; Dicumaol R; Dicumarine; Dicumol; Dikumarol; Dufalone; Kumoran; Melitoxin; Temparin; Trombosan;

Toxicity (Overdose)

LD₅₀=233 mg/kg (orally in mice); LD₅₀=250 mg/kg (orally in rats)

Dosage Forms of Dicumaol R

Tablet Oral

Chemical IUPAC Name

2-hydroxy-3-[(2-hydroxy-4-oxochromen-3-yl)methyl]chromen-4-one

Chemical Formula

C19H12O6

Dicumarol on Wikipedia

https://en.wikipedia.org/wiki/Dicumarol

Organisms Affected

Humans and other mammals